Inflammatory Bowel Diseases - Progress in Basic Research and Clinical Implications by H. Goebell
Clinical implications of basic research in hepatocellular carcinoma.
This short article highlights a recent basic science discovery and discusses how the discovery could impact medical practice. Every other week during the academic year, one student from those enrolled in the PhD portion of the MSTP selects a topic from the column and presents the work. The student's thesis advisor assists in the preparation and also attends the presentation. All students read the primary paper s highlighted in the column and the group discusses the paper s and the clinical implications of the work. The primary goal of this course is to encourage and teach students to continually ask how basic research can impact clinical medicine.
Explore this JAMA Neurology review series devoted to explaining the potential clinical applications of preclinical research and development. This review of preclinical applications assesses the potential of the electronic dura mater to deliver electrical and chemical stimulation to targeted areas of the central nervous system for extended periods. This review discusses the pathogenicity of variants that affect protein levels of TBK1 , the gene associated with amyotrophic lateral sclerosis and frontotemporal dementia. This review assesses the therapeutic potential of the monoclonal antibody to the unique prolyl isomerase Pin1 in the diagnosis and prevention of Alzheimer disease, traumatic brain injury, and chronic traumatic encephalitis. This article discusses how a new therapeutic system has the potential to augment neuronal and glial signaling and activity for basic and translational applications.
Skip to search form Skip to main content. Postoperative pain--clinical implications of basic research. Zahn and Timothy J. Zahn , Timothy J. Postoperative incisional pain is a unique and common form of acute pain. View on PubMed.
Electronic address: roberts. A year old Caucasian female has compensated hepatitis C related cirrhosis. Her surveillance ultrasound showed hypodense liver nodules and subsequent triple phase CT scan showed five tumor nodules with diameters ranging from cms involving both hepatic lobes. The nodules showed characteristic radiologic findings on the CT scan and she was diagnosed with hepatocellular carcinoma HCC based on non-invasive criteria. There was also associated right portal vein tumor thrombosis. Her functional capacity at diagnosis was slightly limited, but she was capable of performing all activities of daily living and self-care. An upper endoscopy was negative for esophageal or gastric varices.
Analytical Essay on the Clinical implications of basic research and basic implications of clinical observations. The New England Journal of Medicine NEJM has a series of publications that explores the bi-directional relationship between basic science and clinical practice. Residents may choose to develop an example of basic science research findings that have led to insights relevant to clinical practice, or clinical findings that pose questions or reveal insights relevant to the basic sciences. A scholar project in these areas should include a directed, comprehensive literature review, and critical appraisal of the evidence. Basic science literature should be derived at least in part from preclinical journals. Although a single basic science concept may be of interest, there should be an effort to seek out the body of evidence on this topic where multiple laboratory studies of the same concept are included.