Clinical significance of bioavailability and bioequivalence

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clinical significance of bioavailability and bioequivalence

Bioavailability & Bioequivalence: Definition & types of bioavailability, factors affecting bioavailablity, methods to assess bioavailabilty, difference between bioequivalence and bioavailability by Yasir Chohan

BIOAVAILABILITY AND BIOEQUIVALENCE STUDIES
Definition, types, factors affecting, methods to assess, importance, difference between bioequivalence and bioavailability
learn the concept of bioavailability
You can learn in very easy words the concept of bioavailability and bioequivalence in this book. What is bioavailability and why we are studying this. Many people considers these two terms as the same thing. In this book you will find the difference between these two terms.
importance of bioavailability studies in pharmacy
New doses are being made on the daily basis. There are many clinical trials going on in different industries on different drugs. The main factor while selecting the dosage form is to check if it is bioavailable or not. The importance of this study is mentioned in this eBook.
Factors affecting bioavailability
When we select a drug and in take by any of the route other than the intravenous there are different factors which are going to affect that drug’s bioavailability. What are those factors which are affecting the drug bioavailability are mentioned in detail for the readers to understand that how with these factors bioavailability is being affected. We can add up on our indication regarding these factors that avoid taking drug with meal containing calcium ions as in case of tetracyclines and different other things mentioned in this chapter so that the drug reaches the systemic circulation and shows its effects.
methods to assess bioavailability
Only the factors and knowledge about this subject do not help us in designing the drug dosage form. Once we develop it we perform different tests to measure the drug bioavailability. There are various methods for this purpose. They are mentioned in this eBook.
About the Author
Yasir Chohan is new Amazon author. He has spent years researching this topic bioavailability and has written this book in very easy words for the readers to understand. He had also searched for the importance of this subject and its different factors and come up with an amazing piece named as ‘Bioavailability and bioequivalence studies’ to share his knowledge with other people. He lives in Reisterstown. He loves to gives advice regarding different home remedies to treat your minor problems. He also loves to help you in different difficult medical topics.
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Bioavailability & Bioequivalence

Bioavailability is referred to as the extent and rate to which the active drug ingredient or active moiety from the drug product is absorbed and becomes available at the site of drug action.
Yasir Chohan

Clinical relevance of the bioavailability/bioequivalence controversy.

Products are not intended to diagnose, cure, or prevent any disease. View Cart. CoQ10 Shop By Brand. Shop By Health Interest. Shop By Category. What is the difference in increased bioequivalence and increased bioavailability?

However, to have a therapeutic effect, it is not sufficient for the active substance to enter the body. The active substance needs to be available in the correct dose at the specific site in the body where it has to work. Also, the active substance needs to reach the target site within a certain time, and be available there for a defined time.
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1. BACKGROUND

If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Drug product performance, 1 in vivo , may be defined as the release of the drug substance from the drug product leading to bioavailability of the drug substance. The assessment of drug product performance is important since bioavailability is related to the pharmacodynamic response and related adverse events. Thus, performance tests relate the quality of a drug product to clinical safety and efficacy. Bioavailability studies are drug product performance studies used to define the effect of changes in the physicochemical properties of the drug substance, the formulation of the drug, and the manufacture process of the drug product dosage form. Bioavailability is one aspect of drug product quality that links the in vivo performance of a new drug product to the original formulation that was used in clinical safety and efficacy studies. Bioequivalence studies are drug product performance tests that compare the bioavailability of the same active pharmaceutical ingredient from one drug product test to a second drug product reference.

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